Association between occupational hazard exposures and small airway function among middle-aged and elderly people
10.3760/cma.j.cn112150-20210819-00811
- VernacularTitle:中老年人群职业有害因素暴露与小气道功能的相关性分析
- Author:
Lulu CHEN
1
;
Jian SU
;
Ran TAO
;
Jiannan LIU
;
Pengfei LUO
;
Shurong LYU
;
Gan LU
;
Jinyi ZHOU
Author Information
1. 江苏省疾病预防控制中心慢性非传染病防制所，南京 210009
- Keywords:
Occupational exposure;
Dust;
Harmful gas;
Small airway function
- From:
Chinese Journal of Preventive Medicine
2021;55(11):1287-1292
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between occupational hazard exposures and small airway function among middle-aged and elderly people.Methods:From July to December in 2015, a multistage cluster random sampling method was used to select 3 600 residents aged 40 years old and above from 6 chronic obstructive pulmonary disease surveillance points in Jiangsu province. A cross-sectional survey was conducted to collect relevant information. Multivariable linear regression model was performed to determine the relationship between occupational hazard exposures and small airway function.Results:A total of 3 347 participants were included in the final analysis, and 44.6% of participants had been exposed to occupational hazard exposures. Compared with participants without the exposure history of occupational hazards, the significantly lower post-bronchodilator FEF 50%, FEF 75% and MMEF levels were observed in those with the exposure history of occupational hazards (β=-82.74, -55.43 and -91.57, respectively). Post-bronchodilator FEF 75% and MMEF (β=-51.78 and -79.47, respectively) in the participants with the exposure history of occupational dust and post-bronchodilator FEF 50%, FEF 75% and MMEF (β=-96.84, -32.87 and -75.72, respectively) in the participants with the exposure history of occupational harmful gas all showed a lower level. Post-bronchodilator FEF 75% was negatively associated with occupational hazard exposures in males (β male=-91.65 vs. β female=-27.21, P for interaction=0.022). Conclusions:The small airway function is worse in the middle-aged and elderly population with the exposure history of occupational hazards, and it is more significant in the male population.
