Genomic investigation of human Streptococcus suis infection in Shandong Province
10.3760/cma.j.cn112150-20210127-00084
- VernacularTitle:山东省人感染猪链球菌基因组特征分析
- Author:
Bin HU
1
;
Jianping WANG
;
Yingchun XU
;
Jun LIU
;
Tao LI
;
Jing JIA
;
Wenguo JIANG
;
Xiujuan BI
;
Xinyi QU
;
Zengqiang KOU
;
Ming FANG
;
Na SUN
;
Ying YANG
;
Dianmin KANG
;
Peibin HOU
Author Information
1. 山东省疾病预防控制中心，济南 250014
- Keywords:
Streptococcus suis;
Meningitis;
High pathogenicity;
Whole genome phylogenetic tree
- From:
Chinese Journal of Preventive Medicine
2021;55(10):1232-1239
- CountryChina
- Language:Chinese
-
Abstract:
To investigate Streptococcus suis ( S.suis) isolated from patients in Shandong province using genomic epidemiology and pathogenologic analysis. To provide the foundation to establish reasonable and accurate prevention and control measures of human S. suis infection. Molecular typing, whole genome phylogenetic tree, virulence gene typing, antibiotic resistance profile and mobile genetic elements carrying antibiotic resistance genes of isolated S. suis strains were investigated. The pathogenicity of isolated strains was also evaluated by comparing their capacity to induce pro-inflammatory cytokine production in vitro. S. suis infections in Shandong province were predominantly due to serotype 2 and sequence type 1 strains. The major symptoms were meningitis. The studied strains could be divided into five lineages. All strains belong to highly pathogenic type in Shandong province,Strains from lineage 2 possessed higher capacity to stimulate pro-inflammatory cytokine production than other strains did, even though other strains belong to highly pathogenic strains. In addition, multiple antibiotic resistance genes and corresponding mobile genetic elements werewidespread in S. suis strains from Shandong province, except strains from lineage 3. High diversities in genome, evolutionary path and pathogenicity of S. suis strains from Shandong province were revealed. It was necessary to surveillant the S. suis strain in genomic level.
