Research progress on iron metabolism in the occurrence and development of periodontitis
10.3724/zdxbyxb-2024-0037
- VernacularTitle:铁代谢在慢性牙周炎发生发展中的作用研究进展
- Author:
Yuting YANG
1
;
Yingming WEI
;
Lili CHEN
Author Information
1. 浙江大学医学院附属第二医院牙周病专科,浙江 杭州 310009
- Keywords:
Chronic periodontitis;
Iron metabolism;
Pathogenic bacterium;
Immune microenvironment;
Periodontal tissue cells;
Review
- From:
Journal of Zhejiang University. Medical sciences
2024;53(5):541-549
- CountryChina
- Language:Chinese
-
Abstract:
Iron metabolism refers to the process of absorption,transport,excretion and storage of iron in organisms,including the biological activities of iron ions and iron-binding proteins in cells.Clinical research and animal experiments have shown that iron metabolism is associated with the progress of periodontitis.Iron metabolism not only enhances the proliferation and toxicity of periodontal pathogens,but also activate host immune-inflammatory response mediated by macrophages,neutrophils and lymphocytes.In addition,iron metabolism is also involved in regulating cellular death sensitivity of gingival fibroblasts and osteoblasts and promoting the differentiation of osteoclasts,which plays a regulatory role in the regeneration and repair of periodontal tissue.This article reviews the research progress on the pathogenesis of periodontitis from the perspective of iron metabolism,aiming to provide new ideas for the treatment of periodontitis.
