Mature oocyte found during ovarian tissue cryopreservation in an early adolescent female
10.3724/zdxbyxb-2023-0561
- VernacularTitle:青春初期女性行卵巢组织冷冻过程中发现成熟卵母细胞一例
- Author:
Haocheng ZHANG
1
,
2
,
3
;
Libing SHI
;
Haichao WANG
;
Haiyan ZHU
Author Information
1. 浙江大学医学院附属邵逸夫医院生殖医学中心,浙江 杭州 310016
2. 浙江省妇产疾病临床医学研究中心,浙江 杭州 310016
3. 浙江省生育力精准保护与促进重点实验室,浙江 杭州 310016
- Keywords:
Fertility preservation;
Early adolescence;
Ovarian;
Refrigeration;
Ovum;
In vitro maturation;
Case report
- From:
Journal of Zhejiang University. Medical sciences
2024;53(4):527-530
- CountryChina
- Language:Chinese
-
Abstract:
A 15-year-old female with Hodgkin's lymphoma underwent ovarian tissue cryopreservation for preserving fertility in Reproductive Department of Sir Run Run Shaw Hospital,Zhejiang University School of Medical after receiving one course of chemotherapy.During the ovarian tissue cryopreservation,one MⅡmature oocyte and three germinal vesicle oocytes were found.The three immature oocytes underwent in vitro maturation but failed.Ultimately,one mature oocyte and 12 ovarian cortex slices were cryopreserved using vitrification.This case indicates that for patients with established gonadal axis feedback,ovarian tissue cryopreservation may not be the only method for fertility preservation.It is advisable to consider ovarian stimulation and oocyte retrieval for oocyte cryopreservation.Alternatively,for individuals in the ovulation phase of their menstrual cycle,attempting oocyte retrieval before ovarian tissue cryopreservation to obtain mature oocytes from the natural cycle,followed by oocyte cryopreservation,may enhance the likelihood of successful fertility preservation.
