Advances on T cell immunity in bone remodeling and bone regeneration
10.3724/zdxbyxb-2023-0619
- VernacularTitle:T细胞免疫在骨重建和骨再生中的研究进展
- Author:
Wenhui HU
1
;
Jinxia DENG
;
Zhanpeng SU
;
Haixing WANG
;
Sien LIN
Author Information
1. 广东医科大学附属医院骨科中心,广东 湛江 524000
- Keywords:
Osteoimmunology;
T cells;
Adaptive immunity;
Bone remodeling;
Bone regeneration;
Osteoporosis;
Union of fracture;
Review
- From:
Journal of Zhejiang University. Medical sciences
2024;53(4):450-459
- CountryChina
- Language:Chinese
-
Abstract:
Bone remodeling and bone regeneration are essential for preserving skeletal integrity and maintaining mineral homeostasis.T cells,as key members of adaptive immunity,play a pivotal role in bone remodeling and bone regeneration by producing a range of cytokines and growth factors.In the physiological state,T cells are involved in the maintenance of bone homeostasis through interactions with mesenchymal stem cells,osteoblasts,and osteoclasts.In pathological states,T cells participate in the pathological process of different types of osteoporosis through interaction with estrogen,glucocorticoids,and parathyroid hormone.During fracture healing for post-injury repair,T cells play different roles during the inflammatory hematoma phase,the bone callus formation phase and the bone remodeling phase.Targeting T cells thus emerges as a potential strategy for regulating bone homeostasis.This article reviews the research progress on related mechanisms of T cells immunity involved in bone remodeling and bone regeneration,with a view to providing a scientific basis for targeting T cells to regulate bone remodeling and bone regeneration.
