Urine proteomics signatures associated with alcohol drinking among residents attending the National Upper Gastrointestinal Cancer Early Detection Program in Linqu, Shandong province
10.3760/cma.j.cn112150-20210312-00247
- VernacularTitle:山东省临朐县参与国家上消化道癌早诊早治项目居民饮酒相关尿蛋白质组学特征
- Author:
Hua FAN
1
;
Xue LI
;
Nairen ZHENG
;
Sha HUANG
;
Tong ZHOU
;
Zhexuan LI
;
Yang ZHANG
;
Jingying ZHANG
;
Weicheng YOU
;
Kaifeng PAN
;
Wenqing LI
Author Information
1. 北京大学肿瘤医院 北京市肿瘤防治研究所流行病学研究室 100142
- Keywords:
Alcohol drinking;
Proteomics;
Pathway enrichment analysis
- From:
Chinese Journal of Preventive Medicine
2021;55(9):1139-1144
- CountryChina
- Language:Chinese
-
Abstract:
The liquid chromatography tandem mass spectrometry was used to detect the urinary proteomics of 223 residents aged 40-69 years old who participated in the National Upper Gastrointestinal Cancer Early Detection Program in Linqu County, Shandong Province from November 22 to December 7, 2018, and analyze the alcohol consumption related proteomic profiles and individual urinary protein. There were significant differences in urinary protein profiles between alcohol consumption group and non-alcohol consumption group. The expression of 26 urinary proteins was up-regulated and 20 urinary proteins were down-regulated in alcohol consumption group ( P<0.05). The differentially expressed proteins had enzyme inhibitor activity and phospholipid binding function, and mainly enriched in pathways involving proximal tubule bicarbonate regeneration, complement and coagulation cascade, and cholesterol metabolism. The protein expressions of complement factor I (CFI), angiotensin converting enzyme 2 (ACE2) and protein C inhibitor (SERPINA5) were positively correlated with daily alcohol consumption.
