Research progress on Hippo signaling pathway effector molecules in rheumatic immune system diseases
10.3724/zdxbyxb-2023-0567
- VernacularTitle:Hippo信号通路效应分子在风湿免疫系统疾病中的作用研究进展
- Author:
Jie GAO
1
,
2
;
Caihong PI
;
Junmei PAN
;
Wei ZHOU
Author Information
1. 扬州大学附属医院风湿免疫科,江苏 扬州 225003
2. 大连医科大学研究生院,辽宁 大连 116044
- Keywords:
Hippo signaling pathway;
Rheumatism;
Pathogenesis;
Review
- From:
Journal of Zhejiang University. Medical sciences
2024;53(3):376-381
- CountryChina
- Language:Chinese
-
Abstract:
The core components of the Hippo signaling pathway encompass upstream regulatory molecules,core kinase cascade complexes,and downstream transcriptional regulation complexes.This pathway modulates cellular behaviors by influencing the effector molecules of its core components and plays a pivotal role in immune regulation.Effector molecules,such as Yes-associated protein(YAP),transcriptional coactivator with PDZ-binding motif(TAZ),transcriptional enhanced associate domain transcriptional factor(TEAD),monopolar spindle-one binder(MOB1),large tumor suppressor(LATS),can stimulate fibroblast-like synovial cell migration and invasion in rheumatoid arthritis,regulate osteoarthritis disease progression,promote pathological new bone formation in ankylosing spondylitis,sustain submandibular gland development while delaying Sjogren's syndrome progression,mediate alpha-smooth muscle actin in systemic sclerosis,and refine the regulation of target genes associated with pulmonary fibrosis.This article provides an overview of the regulatory mechanisms involving Hippo signaling pathway-related effector molecules in the pathogenesis and progression of rheumatic immune system diseases,to serve as a reference for exploring novel therapeutic targets of rheumatic immune system diseases.
