Research progress on the prevention and treatment of chemotherapy-induced ovarian damage
10.3724/zdxbyxb-2023-0495
- VernacularTitle:化学疗法所致卵巢损伤的防治研究进展
- Author:
Yuxin ZHA
1
;
Yang LI
;
Weiguo LYU
Author Information
1. 浙江大学医学院附属妇产科医院肿瘤科,浙江 杭州 310006
- Keywords:
Chemotherapy;
Injury of ovary;
Ovarian protection;
Mechanism;
Review
- From:
Journal of Zhejiang University. Medical sciences
2024;53(3):288-296
- CountryChina
- Language:Chinese
-
Abstract:
Chemotherapy is a main treatment option for malignant tumors,but it may cause various adverse effects,including dysfunction of female endocrine system and fertility.Chemotherapy-induced ovarian damage has been concerned with ovarian preservation but also the prevention and treatment of ovarian dysfunction.In this article,the mechanisms of ovarian injury caused by chemotherapy,including apoptosis of the follicle and supporting cells,follicle"burn out",ovarian stromal and microvascular damage;and influencing factors,including age at diagnosis,initial low pre-treatment anti-Müllerian hormone levels,toxicity,dose and regimen of chemotherapy drugs are reviewed based on the latest research results and clinical practice.The article also discusses measures and frontier therapies for the prevention and treatment of ovarian injury,including the application of gonadotropin releasing hormone agonists or antagonists,tyrosine kinase inhibitors,antioxidants,sphingosine-1-phosphate,ceramide-1-phosphate,mammalian target of rapamycin inhibitors,granulocyte-colony stimulating factor,stem cell therapy and artificial ovaries.
