Midbody remnant regulates the formation of primary cilia and their roles in tumor growth

VernacularTitle:中间体残体与初级纤毛的关系及其在肿瘤生长中的作用
Author: Zhengyang LI ¹ ; Huiming ZHAO ; Subing LI ; Zuoyi JIAO
Author Information

1. 兰州大学第二临床医学院,甘肃兰州 730030
Keywords: Tumor; Cell mitosis; Midbody remnant; Primary cilium; Review
From: Journal of Zhejiang University. Medical sciences 2024;53(2):261-268
CountryChina
Language:Chinese
Abstract: Recent studies have shown that the formation of the primary cilium is associated with a specific cellular organelle known as the midbody remnant(MBR),which is a point-like organelle formed by shedding of the midbody at the end of mitosis.MBRs move along the cell surface close to the center body and regulate it to form primary cilia at the top of the centriole.Primary cilia can act as an organelle to inhibit tumorigenesis,and it is lost in a variety of tumors.Studies have shown that the accumulation of MBRs in tumor cells affects ciliogenesis;in addition,both MBRs and primary cilia are degraded in tumor cells through the autophagy pathway,and MBRs can also transfer tumor signaling pathway factors to primary cilia affecting tumorigenesis.In this article,the basic structure and the formation process of MBR and primary cilia are reviewed and the mechanism of MBRs regulating ciliogenesis is elaborated.The significance of MBR-mediated ciliogenesis in tumorigenesis and its potential as a target for cancer treatment are discussed.