Research progress on the pathogenesis of chest tightness variant asthma characterized by chest tightness
10.3724/zdxbyxb-2023-0442
- VernacularTitle:以胸闷为特点的胸闷变异性哮喘发病机制研究进展
- Author:
Luanqing CHE
1
;
Jianxing LAI
;
Huaqiong HUANG
;
Wen LI
;
Huahao SHEN
Author Information
1. 浙江大学医学院附属第二医院呼吸与危重症医学科 浙江省呼吸疾病诊治及研究重点实验室,浙江 杭州 310009
- Keywords:
Chest tightness;
Chest tightness variant asthma;
Perception;
Psychosis;
Airway inflammation;
Mechanism;
Review
- From:
Journal of Zhejiang University. Medical sciences
2024;53(2):213-220
- CountryChina
- Language:Chinese
-
Abstract:
Chest tightness variant asthma(CTVA)is an atypical form of asthma with chest tightness as the sole or predominant symptom.The underlying receptors for chest tightness are bronchial C-fibers or rapidly adapting receptors.The nerve impulses are transmitted via the vagus nerve and processed in different regions of the cerebral cortex.Chest tightness is associated with sensory perception,and CTVA patients may have heightened ability to detect subtle changes in lung function,but such sensory perception is unrelated to respiratory muscle activity,lung hyperinflation,or mechanical loading of the respiratory system.Airway inflammation,pulmonary ventilation dysfunction(especially involving small airways),and airway hyperresponsiveness may underlie the sensation of chest tightness.CTVA patients are prone to comorbid anxiety and depression,which share similar central nervous system processing pathways with dyspnea,suggesting a possible neurological basis for the development of CTVA.This article examines the recognition and mechanisms of chest tightness,and explores the pathogenesis of CTVA,focusing on its association with airway inflammation,ventilation dysfunction,airway hyperresponsiveness,and psychosocial factors.
