Effects of different calcium intakes on metabolism in healthy adults under strict dietary intervention
10.3760/cma.j.cn112150-20201115-01370
- VernacularTitle:严格膳食干预下不同钙摄入量对中国健康成年人机体代谢的影响
- Author:
Ran LI
1
;
Xing MENG
;
Yong WANG
;
Chunbo WEI
;
Jian GAO
;
Xiaoyu GUO
;
Ying LI
Author Information
1. 哈尔滨医科大学公共卫生学院 150081
- Keywords:
Calcium;
Diet;
Randomized controlled trial;
Metabolomics
- From:
Chinese Journal of Preventive Medicine
2021;55(8):965-972
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of different calcium intakes on metabolism in healthy adults with traditional Chinese dietary pattern.Methods:A total of 64 college students (32 males and 32 females) were recruited from the School of Public Health, Harbin Medical University from September to October 2015. A prospective, randomized, double-blind, placebo-controlled trial design (RCT trial) was used to strictly control the diet of the volunteers through meal preparation, so that the background of the experimental and the control group was exactly the same. In our study, 64 healthy adults were randomly divided into two groups (calcium supplementation and control). The two groups were given the same diet every day. One group was given 400 mg/d of calcium supplementation, which was close to the recommended intake in China (800 mg/d); the other group was given pacebo, the average calcium intake was close to the average intake of Chinese (400 mg/d), calcium intervention lasted for 35 days. Serum and urine samples from pre-intervention, mid-intervention, and post-intervention were collected for metabolomics studies and detection of serum hormone levels and biochemical indicators. PCA and PLS-DA were used to compare the differences in serum and urine metabolites. After adjusting for age and BMI, the differences of hormones [parathyroid hormone, 1, 25(OH) 2D 3] and biochemical indicators were compared by repeated measurement variance analysis. Results:The 64 subjects were aged 23-28 years, including 32 males and 32 females. The baseline characteristics of the calcium supplementation group and the control group were balanced. The results showed that there were no significant differences in blood and urine metabolites, metabolic hormone [parathyroid hormone, 1, 25(OH) 2D 3] levels and biochemical indicators(serum Ca, serum P, glycolipid metabolism and hepatorenal function indicators)between the calcium supplementation group and control group at each time point throughout the trail ( P>0.05). Conclusion:No health hazards associated with calcium deficiency was observed in healthy adults in the short term at current calcium intake level (300-400 mg/d).
