Research progress on the role of TANK-binding kinase 1 in anti-virus innate immune response

VernacularTitle:TANK结合激酶1在抗病毒免疫应答中的作用研究进展
Author: Xue WANG ¹ ; Yuchuan ZHANG ; Wei CHEN
Author Information

1. 浙江大学医学院免疫学研究所
Keywords: TANK-binding kinase 1/immunology; Viral infection; Interferon type I/immunology; Interferon regulatory factor-3; Review
From: Journal of Zhejiang University. Medical sciences 2016;45(5):549-556
CountryChina
Language:Chinese
Abstract: The innate immune response against viral infection is mainly relies on type I interferon , the production of which is mediated by TANK-binding kinase 1 ( TBK1 ) .It is revealed that the downstream TBK 1 is activated by viral nucleic acid sensors RIG-I, cGAS and TLR3.The activity of TBK1 is complexly and precisely regulated by different type of protein modifications , including phosphorylation , ubiquitination and Sumolylation .This article focuses on the role of TBK 1 in anti-viral innate immunity and the regulatory mechanism for the TBK 1 activation.