Progress on anti-tumor molecular mechanisms of dihydroartemisinin
10.3785/j.issn.1008-9292.2016.09.08
- VernacularTitle:双氢青蒿素抗肿瘤分子生物学机制研究进展
- Author:
Peng CAO
1
;
Dongjin LENG
;
Ying LI
;
Ziwei ZHANG
;
Lei LIU
;
Xiaoyan LI
Author Information
1. 东北林业大学生命科学学院
- Keywords:
Artemisinin/analogs & derivatives;
Artemisinin/pharmacology;
Antineoplastic drugs ( TCD )/ therapeutic use;
Apoptosis/drug effects;
Cell proliferation/drug effects;
Neoplasm invasiveness;
Neoplasm metastasis;
Review
- From:
Journal of Zhejiang University. Medical sciences
2016;45(5):500-506
- CountryChina
- Language:Chinese
-
Abstract:
Artemisinin is an anti-malarial drug with poor water solubility and oral absorption; so a variety of derivatives based on the parent nucleus have been developed.Compared with artemisinin , dihydroartemisinin (DHA) has a stronger anti-malaria activity, and has the advantages of high metabolic rate and better water solubility .Recent studies have discovered that DHA has a good inhibitory effect on tumor cells, which is closely related to the peroxide bridge in its molecular structure . Since tumor cells need more Fe 3+ than normal cells, there are a large number of transferrin receptors on the tumor cell membrane .DHA can break the peroxide bridge in the presence of Fe 2+, and the free radicals generated can play its lethal effect on tumor cells.In addition, DHA can promote endocytosis of transferrin receptor , and thus prevent cancer cells from taking Fe 3+from microenvironment .This article reviews the anti-tumor molecular mechanism of DHA , including accelerating oxidative damage , inducing apoptosis , inhibiting the growth , proliferation and invasion of tumor cells , reversing tumor multidrug resistance .
