Influence of As2 O3-lipiodol emulsion via transarterial embolization on a VX2 liver tumor model in rabbits
10.3785/j.issn.1008-9292.2015.09.14
- VernacularTitle:经肝动脉三氧化二砷碘油乳化剂栓塞对兔VX2肝癌模型的作用
- Author:
Yu ZOU
1
;
Chuan-Gen GUO
;
Shun-Liang XU
;
Zhi-Yi PENG
;
Jun-Hui SUN
Author Information
1. 浙江大学医学院附属妇产科医院放射科
- Keywords:
As2 O3;
Embolization;
VX2 cell line;
Hepatocellular carcinoma;
Therapy
- From:
Journal of Zhejiang University. Medical sciences
2015;(5):559-565
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the anticancer efficacy and the hepatic and renal toxicity of As 2 O3-lipiodol emulsion via transarterial embolization in a rabbit VX 2 liver tumor model .Methods:VX2 tumors were implanted in rabbit livers successfully , followed by transarterial embolization with high-dose As2 O3 ( 5 mg/kg with 0.2 mL lipiodol, n =10), low-dose As2O3 (1 mg/kg with 0.2 mL lipiodol, n =10), and control ( 0.2 mL lipiodol , n=10 ) . The growth ratios and microvessel densities ( MVDs ) of the tumors were estimated by multi-row spiral CT and CD34 immunohistochemical staining , respectively . Hepatic and renal function was also evaluated by means of blood biochemical analysis .Results: The growth ratios of the tumors differed significantly among three groups ( P<0.01 ) .The high-dose and low dose group showed significantly lower tumor growth ratios [ 44.05%( -36.40% ~64.60%) , 95.20%( -11.60% ~159.40%) ] than control group [ 145.55%(98.90%~250.30%) , all P<0.05 ] .The MVDs of the tumors were significantly lower in the high-dose (21.4 ±10.6 ) and low-dose group(34.1 ±12.0 ) than those in control group (57.9 ±16.1 ,all P<0.05 ) .The levels of blood ALT and AST obtained 28 days after transarterial embolization were significantly lower in the high-dose [(25.50 ±12.37)U/L,(24.25 ±10.89)U/L] and low-dose group[(45.00 ±14.04) U/L,(35.22 ±11.86)U/L] than in control group[(79.12 ±30.52)U/L,(75.25 ± 25.89 ) U/L, all P <0.05 ] .Conclusion: As2 O3-lipiodol emulsion via transarterial embolization has anticancer effect without significant hepatic and renal functional damage in rabbit VX2 liver tumors.
