Rees arch progress in toxico logy of molecular targeted anticancer drugs
10.3785/j.issn.1008-9292.2015.09.01
- VernacularTitle:分子靶向抗肿瘤药物的毒性研究进展
- Author:
Xiao-E LOU
1
;
Min CHEN
;
Bo YANG
Author Information
1. 浙江大学药学院药理毒理与生化药学研究所
- Keywords:
Antineoplastic agents/toxicity;
Protein-tyrosine kinases/antagonists &inhibitors;
Protein-tyrosine kinases/adverse effects;
Heart/drug effects;
Liver/drug effects;
Lung/drug effects;
Skin diseases/etiology;
Review
- From:
Journal of Zhejiang University. Medical sciences
2015;(5):473-478
- CountryChina
- Language:Chinese
-
Abstract:
[A bstratc ] Objective:Drug therapy is essential for cancer treatment .The molecular targeted anticancer drugs develop rapidly in recent years , since the effectiveness of traditional chemotherapy is unsatisfactory and the adverse reactions are high .However , molecular targeted anticancer drugs would damage the function of heart , liver or lung , and may cause adverse effects such as hand f-oot syndrome , which restrains their clinical application.Therefore, it is critical for pharmaceutical toxicology to study the toxicity , the related mechanisms and the preventive measures of molecular targeted anticancer drugs.
