Distribution of HCV genotypes in Chinese Han population with chronic hepatitis C
10.3785/j.issn.1008-9292.2015.07.11
- VernacularTitle:丙型肝炎病毒基因型在中国大陆汉族慢性丙型肝炎患者中的分布特征
- Author:
Xiao-Rong MAO
1
;
Li-Ting ZHANG
;
Ni JIANG
;
Ping XIAO
;
Xue-Bin PENG
;
You-Cheng ZHANG
Author Information
1. 兰州大学第一医院感染科
- Keywords:
Hepatitis C/virology;
Hepatitis viruses/genetics;
Genotype;
Hepatitis,chronic/virology;
Sequence analysis;
Genes,viral/genetics;
China;
Sex distribution
- From:
Journal of Zhejiang University. Medical sciences
2015;(4):417-422
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the distribution of HCV genotypes in Chinese Han population with chronic hepatitis C ( CHC ) . Methods: This randomized multicenter study included 1 014 CHC patients from 28 hospitals in different regions of China.SPSS 20.0 was applied to analyze the relationship among region, HCV genotype, gender and the replication level of HCV-RNA.Results: HCV 1 genotype (56.80%) was the most common genotype.The majority of CHC patients were of genotype 1, 2, 3, 6 in the order of frequency, except those in southwestern, southern and central China.HCV 1, 2, 3, 6 genotypes were most common among male patients in southern China; among female patients in northern China; among male patients in northern and northwestern China and among male patients in northwestern China, respectively ( all P <0 .05 ) .There was no statistical significance between different genders in other regions.The high viral load was more common than the low viral load among HCV 1, 2, 3, 6 genotype-infected patients.Conclusion: There are different distributions of HCV genotypes among the different regions. In addition, HCV genotypes are correlated with gender and HCV-RNA load.
