Survey of antibody levels of pertussis, diphtheria and tetanus in 495 pregnant women in Nanshan District of 2019, Shenzhen
10.3760/cma.j.cn112150-20200331-00481
- VernacularTitle:2019年深圳市南山区495名孕妇百日咳、白喉、破伤风抗体水平调查
- Author:
Tiantian WANG
1
;
Meng YUAN
;
Yuan GAO
;
Hui CHEN
;
Bingqing ZHU
;
Zhujun SHAO
;
Yongxiang DUAN
Author Information
1. 深圳市南山区疾病预防控制中心微生物检验科 518054
- Keywords:
Whooping cough;
Diphtheria;
Tetanus;
Pregnant women;
Antibody
- From:
Chinese Journal of Preventive Medicine
2021;55(4):521-527
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The purpose of this study was to investigate the IgG antibody levels of whooping cough, diphtheria, and tetanus in pregnant women in Nanshan District.Methods:From January to March 2019, 495 pregnant women who met the inclusion criteria in a hospital in Nanshan District, Shenzhen were selected as the survey subjects. The enzyme-linked immunosorbent assay was used to detect serum levels of pertussis, diphtheria, and tetanus IgG antibodies and we compared the differences in antibody levels of pregnant women with different characteristics.Results:The maternal age was (29.23±4.08) years old. The geometric mean concentration of pertussis antibody was 2.589 (1.172-4.953) IU/ml, 1.01% (5 cases) of pregnant women had pertussis antibody concentration ≥ 40 IU/ml, and 75.15% (372 cases) of pregnant women had pertussis antibody concentration<5 IU/ml. The GMC value and antibody positive rate of diphtheria in pregnant women were 0.024(0.009-0.065) IU/ml and 72.53% (359 cases), respectively. The GMC value and antibody positive rate of tetanus in pregnant women were 0.014 (0.006-0.034) IU/ml and 53.74% (266 cases), respectively. There was no statistical difference in the antibody level and antibody positive rate among pregnant women of diphtheria and tetanus, respectively.Conclusion:The concentration of antibodies against pertussis, diphtheria, and tetanus in pregnant women are all at a low level, which is not enough to protect themselves from disease infection.
