Comparison clinical efficacy of 3%hypertonic saline solution with 20%mannitol in treatment of intracranial hypertension in patients with aneurysmal subarachnoid hemorrhage
10.3785/j.issn.1008-9292.2015.07.07
- VernacularTitle:高渗盐水和甘露醇在动脉瘤性蛛网膜下腔出血患者降低颅内压中的应用
- Author:
Xue-Cai HUANG
1
;
Ling-Ling YANG
Author Information
1. 丽水市中心医院神经外科
- Keywords:
Mannitol/administration&dosage;
Subarachnoid hemorrhage/therapy;
Intracranial hypertension/drug therapy;
Intracranial hypertension/complications;
Saline solution,hypertonic/administration & dosage;
Drug therapy,combination;
Treatment outcome;
Random allocation
- From:
Journal of Zhejiang University. Medical sciences
2015;(4):389-395
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the efficacy of 3%hypertonic saline solution with 20% mannitol in treatment of intracranial hypertension in patients with aneurysmal subarachnoid hemorrhage.Methods: An alternating treatment protocol was used to compare the efficacy of 160 mL 3% hypertonic saline solution ( HSS ) with 150 mL 20%mannitol for episodes of increased intracranial pressure ( ICP ) in patients with aneurysmal subarachnoid hemorrhage.The dependent variables were the extent and duration of reduction of increased ICP after each event.Results: Both 3% HSS and 20% mannitol rapidly decreased the ICP in patients with aneurysmal subarachnoid hemorrhage ( P <0.01 ) .No difference between two medications in the extent of duration of ICP and reduction of action ( P>0.05) .Conclusion:3%HSS should be considered as the first-line osmotic drug in treatment of intracranial hypertension in patients with aneurysmal subarachnoid hemorrhage.
