Malnutrition in early life and cardiovascular disease in adulthood
10.3785/j.issn.1008-9292.2015.05.18
- VernacularTitle:生命早期营养不良与成年期心血管功能的关系
- Author:
Lin-Jiang LAO
1
;
Li-Yan ZHANG
;
Li-Zhong DU
Author Information
1. 浙江大学医学院附属儿童医院新生儿科
- Keywords:
Cardiovascular diseases/etiology;
Cardiovascular diseases/epidemiology;
Fetal development;
Malnutrition;
Models,animal;
Review
- From:
Journal of Zhejiang University. Medical sciences
2015;(3):349-353
- CountryChina
- Language:Chinese
-
Abstract:
Epidemiological and experimental studies have demonstrated that the risk of cardiovascular disease ( CVD) in adulthood is influenced by the environment in early life.Intrauterine and early postnatal malnutrition and the following catch-up growth have a long-term effect on blood pressure and endothelial function in adulthood . Well-established prenatal or/and postnatal animal models are used to study the impact of different nutritional intervention on CVD in adulthood .This article reviews the early original cause of chronic CVD in adulthood with the hypothesis of DOHaD ( the developmental origins of health and disease ) , and proposes possible preventions in early life on the basis of this theory .
