The research progress of circular RNAs in the development and progression of cervical cancer

VernacularTitle:环状RNA在宫颈癌发生发展中作用的研究进展
Author: Wei SUN ¹ ; Jiang LI ; Zhuoyu YANG ; Yadi ZHENG ; Zheng WU ; Yan WEN ; Dong HANG ; Ni LI
Author Information

1. 南京医科大学第一附属医院　江苏省人民医院妇科，南京　210029
Keywords: Cervical cancer; Human papilloma virus; Circular RNA; miRNA sponge
From: Chinese Journal of Preventive Medicine 2021;55(3):409-412
CountryChina
Language:Chinese
Abstract: Cervical cancer is one of the most common gynecological malignancies, and its morbidity and mortality are among the highest. Persistent infection of high-risk types of HPV is the main reason for its onset, with types 16 and 18 being the most prevalent. Circular RNA (circRNA) is a single-stranded circular non-coding RNA formed by covalent end to end bonding of RNA precursors. It has functions such as miRNA sponge, binding RNA binding protein (RBP), and protein translation, and plays an important role in the occurrence and development of various diseases. At present, the research on circRNA in cervical cancer is still at an early stage. The latest progress of circRNA in high-risk HPV infection, occurrence and development of cervical cancer, and sensitivity to chemoradiotherapy is briefly reviewed.