Progress on interleukin-27 in tumor immunity
10.3785/j.issn.1008-9292.2015.03.017
- VernacularTitle:白细胞介素27及其与肿瘤关系的研究进展
- Author:
Jia HE
1
;
Qing-Qing WANG
Author Information
1. 浙江大学医学院免疫学研究所
- Keywords:
Interleukins;
Neoplasms;
Review
- From:
Journal of Zhejiang University. Medical sciences
2015;(2):223-228
- CountryChina
- Language:Chinese
-
Abstract:
As a member of IL-6/IL-12 cytokine family , IL-27 is a heterodimeric cytokine composed of the p 28 and EBI3 .Functioning as a linkage between innate and adaptive immunity , IL-27 is mainly produced by activated antigen-presenting cells and has a variety of responder cells including T cells , NK cells, macrophages and dendritic cells.IL-27 plays an antitumor role through promoting the production of cytotoxic T cells, regulating the differentiation of T cell subsets , enhancing the function of NK cells and inhibiting the angiogenesis .On the other hand , IL-27 may also have a positive effect on tumor progress and metastasis .IL-27 can be used as a reference marker for tumor diagnosis , due to its relation to the occurrence and development of tumors .This article reviews the research progress on the roles of IL-27 in tumor biological regulation .
