Research progress on epithelial-mesenchymal transition in cancer recurrence and metastasis
10.3785/j.issn.1008-9292.2015.03.015
- VernacularTitle:上皮-间质转化在肿瘤发生发展中的作用研究进展
- Author:
Zhi-Xian LIU
1
;
Er-Qing WEI
;
Yun-Bi LU
Author Information
1. 浙江大学医学院药理学系
- Keywords:
Neoplasms;
Cadherins;
Transcription factors;
Stromal cells/pathology;
Epithelial cells/pathology;
Biotransformation;
Review
- From:
Journal of Zhejiang University. Medical sciences
2015;(2):211-216
- CountryChina
- Language:Chinese
-
Abstract:
Epithelial-mesenchymal transition ( EMT ) is a process in which epithelial cells lose their morphology and function and gradually transformed into mesenchymal-like cells. It is considered that EMT is the main cause for tumor recurrence and metastasis .Many factors are involved in the regulation of EMT , such as E-cadherin , transforming growth factor-β, Wnt signaling pathway , microRNA and EMT-related transcription factors .This article reviews the research progress on EMT and the involved mechanisms , and thus to provide a new perspective on cancer therapy in the future .
