Progress on association between autophagy and cancer
10.3785/j.issn.1008-9292.2015.03.014
- VernacularTitle:自噬与肿瘤关系研究新进展
- Author:
Jian-Ping CAO
1
;
Da-Jing XIA
Author Information
1. 浙江大学医学院公共卫生系
- Keywords:
Neoplasms;
Autophagy;
Review
- From:
Journal of Zhejiang University. Medical sciences
2015;(2):204-210
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is an evolutionarily well conserved cellular catabolic process . Cellular proteins and organelles are engulfed to autophagosomes and eventually delivered to lysosomes for degradation .Autophagy is closely associated with a variety of human diseases especially cancer .At present , it has been widely accepted that autophagy is a“double-edged sword” in cancer: it blocks tumorigenesis at the early stage , while it facilitates tumor development at the promotion and progression stage . Moreover , autophagy can be induced by chemotherapy and radiotherapy , which is generally play a pro-survival function .Thus, autophagy is an important target for cancer therapy , and suppression of autophagy to enhance the efficacy of cancer therapeutic agents is a novel strategy in cancer therapy under active clinical trials .
