Progress on matrix metalloproteinase in axonal regeneration
10.3785/j.issn.1008-9292.2015.01.016
- VernacularTitle:基质金属蛋白酶影响中枢轴突再生的研究进展
- Author:
Yu-Ying LI
1
;
Yue-Min DING
;
Xiong ZHANG
Author Information
1. 浙江大学医学院基础医学系
- Keywords:
Matrix metalloproteinases;
Extracellular matrix;
Spinal cord injuries/pathology;
Nerve regeneration;
Axons;
Review
- From:
Journal of Zhejiang University. Medical sciences
2015;(1):95-100
- CountryChina
- Language:Chinese
-
Abstract:
Matrix metalloproteinases ( MMPs) are zinc-dependent endopeptidases . MMPs can degrade and remodel extracellular matrix , also active or inactive many molecules attaching to matrix including receptors , growth factors and cytokines , so that injury-induced MMPs can change the extracellular environment to affect the axonal regeneration in central nervous system .In this review, with spinal cord injury (SCI) as an example we discuss the effects of MMPs on inflammation , neuronal viability , extracellular molecules , glial scar and axonal remyelination , which are all important to axonal regeneration .
