Association of blood lead level with cognition impairment among elderly aged 65 years and older in 9 longevity areas of China
10.3760/cma.j.cn112150-20200728-01066
- VernacularTitle:中国9个长寿地区65岁及以上人群血铅浓度与认知功能受损的关联研究
- Author:
Mingyuan ZHANG
1
;
Yuebin LYU
;
Jinhui ZHOU
;
Feng ZHAO
;
Chen CHEN
;
Qiyue TAN
;
Yingli QU
;
Saisai JI
;
Feng LU
;
Yingchun LIU
;
Heng GU
;
Bing WU
;
Zhaojin CAO
;
Qiong YU
;
Xiaoming SHI
Author Information
1. 中国疾病预防控制中心环境与人群健康重点实验室 中国疾病预防控制中心环境与健康相关产品安全所，北京 100021
- Keywords:
Aged;
Lead;
Cross-sectional studies;
Cognitive impairment
- From:
Chinese Journal of Preventive Medicine
2021;55(1):66-71
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between blood lead concentrations and cognition impairment among Chinese older adults aged 65 or over.Method:Data was collected in 9 longevity areas from Heathy Aging and Biomarkers Cohort Study between 2017 and 2018. This study included 1 684 elderly aged 65 years and older. Information about demographic characteristics, socioeconomic factors, health status and cognitive function score of respondents were collected by questionnaire survey and physical examination. Venous blood of the subjects was collected to detect the blood lead concentration. Subjects were stratified into four groups ( Q 1- Q 4) by quartile of blood lead concentration. Multivariate logistic regression model was used to analyze the association between blood lead concentration and cognitive impairment. The linear or non-linear association between blood lead concentration and cognitive impairment were described by restrictive cubic splines (RCS). Results:Among the 1 684 respondents, 843 (50.1%) were female and 191 (11.3%) suffered from cognition impairment. After adjusting for confounding factors, the OR value and 95% CI of cognition impairment was 1.05 (1.01-1.10) for every 10 μg/L increase in blood lead concentration in elderly; Compared with the elderly in Q 1, the elderly with higher blood lead concentration had an increased risk of cognitive impairment. The OR value and 95% CIof Q2, Q3 and Q4 groups were 1.19 (0.69-2.05), 1.45 (0.84-2.51) and 1.92 (1.13-3.27), respectively. Conclusion:Higher blood lead concentration is associated with cognitive impairment among the elderly aged 65 years and older in 9 longevity areas in China.
