Association of neutrophil-to-lymphocyte ratio with depressive symptoms among older adults aged 65 years and above in 9 longevity areas of China
10.3760/cma.j.cn112150-20200812-01112
- VernacularTitle:中国9个长寿地区65岁及以上人群中性粒细胞与淋巴细胞比值与抑郁症状的关联研究
- Author:
Xiaochang ZHANG
1
;
Yuebin LYU
;
Jinhui ZHOU
;
Chen CHEN
;
Chengcheng LI
;
Junfang CAI
;
Zhaojin CAO
;
Feng ZHAO
;
Yingchun LIU
;
Heng GU
;
Feng LU
;
Xiaoming SHI
Author Information
1. 中国疾病预防控制中心环境与人群健康重点实验室 中国疾病预防控制中心环境与健康相关产品安全所，北京 100021
- Keywords:
Aged;
Depressive disorder;
Cross-sectional studies;
Neutrophil-to-lymphocyte ratio
- From:
Chinese Journal of Preventive Medicine
2021;55(1):25-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and the risk of depression symptoms among older adults aged 65 and above in 9 longevity areas of China.Methods:Data was collected in 9 longevity areas of China from Healthy Aging and Biomarkers Cohort Study (HABCS) conducted between 2017 and 2018. Finally,2018 elderly aged 65 years and above with complete information on neutrophil count, lymphocyte count and depressive symptoms were included in this study. Information on demographic characteristics, lifestyle, and health status was collected through questionnaire and physical examination. Complete blood counts which included lymphocytes and neutrophils were obtained by testing venous blood samples. Participants were divided into four groups by the quartile of NLR level, i.e. Q1, Q2, Q3, Q4. Logistic regression model was applied to analyze the association of NLR with depression symptoms. Results:Among 2 018 older adults, the mean(±SD) age was 82.6(±10.73), 1 032(51.14%) were male, 390(19.33%) were detected with depressive symptoms. Compared with participants of NLR in the 1 st quartile, the OR(95% CI) of risk for depressive symptoms was 1.47 (0.99, 2.19), 1.67 (1.13, 2.47) and 1.95 (1.32, 2.89), respectively. Conclusion:Increased NLR level is significantly related to depressive symptoms among elderly aged 65 years and above in 9 longevity areas in China.
