Hypouricemic effect of ethanol extracts from Dioscoreae Nipponicae Rhizoma
10.3785/j.issn.1008-9292.2015.1.008
- VernacularTitle:穿山龙醇提取物对高尿酸血症小鼠的治疗作用
- Author:
Hai-Li SHAN
1
;
Rui-Ping SHAN
;
Xu-Chun FU
Author Information
1. 浙江大学医学院附属第二医院药剂科
- Keywords:
DIOSCOREA NIPPONICA/therapeutic use;
Drugs,Chinese herbal;
Hyperuricemia/drug therapy;
Hypoxanthine;
Uric acid;
Disease models,animal
- From:
Journal of Zhejiang University. Medical sciences
2015;(1):49-53
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of ethanol extracts from Dioscoreae Nipponicae Rhizoma on hyperuricemic mice .Methods:The hyperuricemia was induced by gavage of hypoxanthine and subcutaneous injection of potassium oxonate (model A) or subcutaneous injection of uric acid ( model B ) in ICR male mice .The mice in ethanol extracts groups were administrated with Dioscoreae Nipponicae Rhizoma ethanol extracts 5.4 g/kg by gavage , the positive control groups were given with 10 mg/ml allopurinol or 5 mg/ml benzbromarone by gavage , respectively .The plasma uric acid levels were measured by using HPLC .Results: The plasma uric acid levels of model group, control group and ethanol extract group in model A mice were ( 40.03 ± 27.24), (4.08 ±1.47) and (18.10 ±8.87) g/mL(compared with model group, P<0.05 ) , respectively .The plasma uric acid levels of model group , control group and ethanol extract group in model B mice were ( 18.57 ±3.83 ) , ( 4.29 ±2.36 ) and ( 15.36 ±2.71 ) g/mL ( compared with model group , P <0.05 ) , respectively . Conclusion: The ethanol extracts from Dioscoreae Nipponicae Rhizoma have certain hypouricemic effect in hyperuricemic mice induced by hypoxanthine and potassium oxonate or by uric acid .
