Effects of oxygen saturation on all-cause mortality among the elderly over 65 years old in 9 longevity areas of China
10.3760/cma.j.cn112150-20200630-00952
- VernacularTitle:中国9个长寿地区65岁及以上人群血氧饱和度对死亡风险的影响
- Author:
Dan LIU
1
;
Feng ZHAO
;
Qingmei HUANG
;
Yuebin LYU
;
Wenfang ZHONG
;
Jinhui ZHOU
;
Zhihao LI
;
Yingli QU
;
Ling LIU
;
Yingchun LIU
;
Jiaonan WANG
;
Zhaojin CAO
;
Xianbo WU
;
Chen MAO
;
Xiaoming SHI
Author Information
1. 南方医科大学公共卫生学院流行病学系，广州 510515
- Keywords:
Aged;
Longevity;
Cohort studies;
Oxygen saturation;
Mortality risk
- From:
Chinese Journal of Preventive Medicine
2021;55(1):45-52
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between oxygen saturation (SpO 2) and risk of 3-year all-cause mortality among Chinese older adults aged 65 or over. Methods:The participants were enrolled from Healthy Aging and Biomarkers Cohort Study in year of 2012 to 2014 in 9 longevity areas in China. In this prospective cohort study, 2 287 participants aged 65 or over were enrolled. Data on SpO 2 and body measurements were collected at baseline in 2012, and data on survival outcome and time of mortality were collected at the follow-up in 2014. Participants were divided into two groups according to whether SpO 2 was abnormal (SpO 2<94% was defined as abnormal). Results:The 2 287 participants were (86.5±12.2) years old, 1 006 were males (44.0%), and 315 (13.8%) were abnormal in SpO 2. During follow-up in 2014, 452 were died, 1 434 were survived, and 401 were lost to follow-up. The all-cause mortality rate was 19.8%, and the follow-up rate was 82.5%. The mortality rate of SpO 2 in normal group was 21.1%, and that of abnormal group was 41.6% ( P<0.001). After adjusting for confounding factors, compared to participants with normal SpO 2, participants with abnormal SpO 2 had increased risk of all-cause mortality with HR (95% CI) of 1.62 (1.31-2.02); HR (95 % CI) was 1.49 (0.98-2.26) for males and 1.71 (1.30-2.26) for females in abnormal SpO 2group, respectively; HR (95% CI) was 2.70 (0.98-7.44) for aged 65-79 years old, 1.22 (0.63-2.38) for aged 80-89 years old, and 1.72 (1.35-2.19) for aged over 90 years old in abnormal SpO 2 group, respectively. Conclusion:Abnormal SpO 2 was responsible for increased risk of 3-year all-cause mortality among Chinese elderly adults.
