The relationship between resting heart rate and all-cause mortality among the Chinese oldest-old aged more than 80: a prospective cohort study
10.3760/cma.j.cn112150-20200629-00944
- VernacularTitle:中国80岁及以上高龄老人静息心率与全因死亡风险的前瞻性队列研究
- Author:
Xin CHENG
1
;
Zhihao LI
;
Yuebin LYU
;
Peiliang CHEN
;
Furong LI
;
Wenfang ZHONG
;
Hailian YANG
;
Xiru ZHANG
;
Xiaoming SHI
;
Chen MAO
Author Information
1. 南方医科大学公共卫生学院流行病学系，广州 510515
- Keywords:
Aged, 80 and over;
Heart rate;
Cohort study;
All-cause mortality
- From:
Chinese Journal of Preventive Medicine
2021;55(1):53-59
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between resting heart rate(RHR) and all-cause mortality among the Chinese oldest-old aged more than 80.Methods:Using a total of seven surveys or follow-ups data (1998, 2000, 2002, 2005, 2008, 2011 and 2014) from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). A total of 17 886 elderly over 80 years old were selected as subjects, their resting heart rate were measured though baseline survey and the survival outcome and death time of the subjects were followed up. The subjects were divided into 6 groups according to their resting heart rate. Cox regression model was used to estimate the effect of resting heart rate on mortality risk. The interaction of age, gender and resting heart rate was also analyzed by likelihood ratio test.Results:The age of subjects M( P25, P75) was 92 (86, 100) years old, including 10 531 females (58.9%) and there were 13 598 participants died, the mortality rate was 195.5 per 1 000 person-years. Multivariate Cox regression analysis showed that compared to the control group (60-69 pbm/min), the hazard ratio of the elderly are 1.06 (95% CI: 1.02, 1.11), 1.09 (95% CI: 1.04, 1.15), 1.23 (95% CI: 1.14, 1.34), 1.25 (95% CI: 1.08, 1.44) in the group of RHR between 70-79, 80-89, 90-99 and ≥100 pbm/min and Pvalues are all less than 0.05. Likelihood ratio test showed that RHR and age had an interaction effect. ( P for interaction=0.011). Conclusion:The risk of all-cause death increased with the increase of resting heart rate and this relationship was stronger between the 80-89 years old people.
