Long-term survival analysis of primary hepatocarcinoma patients received transcatheter arterial chemoembolization plus chemotherapy after radical resection
10.3785/j.issn.1008-9292.2014.11.008
- VernacularTitle:肿瘤根治术后行肝动脉化疗栓塞术联合药物化疗的原发性肝癌患者远期生存分析
- Author:
Guang-Ping QIU
1
;
Jie LIU
;
Hua FAN
Author Information
1. 宁波市第二医院介入科
- Keywords:
Carcinoma,hepatocellular/surgery;
Liver neoplasms/suegery;
Liver neoplasms/pathology;
Hepatic artery;
Chemoembolization,therapeutic;
Postoperative period;
Regression analysis;
Alpha-fetoproteins;
Survival rate
- From:
Journal of Zhejiang University. Medical sciences
2014;(6):683-687
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the survival of hepatocellular carcinoma (HCC) patients received prophylactic use of transcatheter arterial chemoembolization ( TACE) after radical resection.Methods: One hundred and forty-three cases of HCC fromNingbo No.2 Hospital were divided into intervention prevention group, chemotherapyprevention group and comprehensive prevention group according to different methods ofHCC prevention.All patients were followed-up for more than 5 years after TACE,chemotherapy(FOLPOX4) or TACE +FOLPOX4.Cox regression model of multiplefactors analysis was used for analyzing impact factors on HCC prognosis.Survival ratewas compared with Kaplan-meier method.Results: Alpha-fetoprotein (AFP) wasnegatively correlated with the survival time of patients, as an independent risk factorwith the regression coefficient of 0.01 and the relative risk of 1.00.Prevention ofpostoperative increased survival time of patients with HCC, which was a protectivefactor.The regression coefficient for comprehensive prevention was -2.37 and therelative risk was 0.07, the weight of comprehensive prevention on lifetime was higherthan that of other two prevention methods, followed by TACE prevention group.One-year, 2-year, 3-year cumulative survival rates in comprehensive prevention groupwere 78.35%, 69.16%, 24.43%, that in TACE prevention group were 76.87%,62.48%, 24.72%, and that in chemotherapy prevention group were 62.23%,43.22%, 19.54%, respectively.Conclusion: AFP was negative correlation with thesurvival time of postoperative HCC patients, monitored which of postoperative HCCpatients can provide a reference for effect and prognosis of surgery.Application ofTACE in HCC patients with postoperative effective in reducing mortality, which prolongthe survival time of HCC patients might be extended further by combined chemotherapybased on its own advantages and disadvantages.
