Advances in genes and molecular markers of pheochromocytoma

VernacularTitle:嗜铬细胞瘤相关遗传基因及分子标志物研究进展
Author: Shi-Kun GONG ¹ ; Zhong LIU
Author Information

1. 浙江大学医学院附属第一医院心内科
Keywords: Pheochromocytoma/genetics; Adrenal gland neoplasms/genetics; Molecular biology; Mutation; Genes; Review
From: Journal of Zhejiang University. Medical sciences 2014;(2):227-233
CountryChina
Language:Chinese
Abstract: Pheochromocytoma is a tumor derived from chromaffin tissue in the adrenergic system with excessive secretion of catecholamine .Pheochromocytoma occurs at any age of patients ,commonly in 40-60 years,and the incidence is slightly higher in women than in men .In recent years , studies have shown that the mutations of von Hippel-Lindau gene ( VHL ) , rearranged during transfaction gene ( RET ) , neurofibromatosis type 1 gene ( NF-1 ) , succinate dehydrogenase gene ( SDH ) , transmembrane protein 127 gene ( TMEM127 ) , myelocytomatosis oncogene-associated factor X gene ( MAX ) are associated with pheochromocytoma .Immunohistochemical studies have revealed that a number of molecular markers ,such as telomerase,vascular endothelial growth factor , cyclooxygenase-2 , adrenomedullin , plasma chromaffin protein A,signal transducer and activator of transcription-3 are of velue in identification of tumor origin, its biological behaviors and differentiation of pheochromocytoma .This article reviews the newest research progresses in molecular biology of pheochromocytoma .