Research progress on biological toxicity of zinc oxide nanoparticle and its mechanism

VernacularTitle:纳米氧化锌的毒性作用及机制研究进展
Author: Xia YANG ¹ ; Mi-Zu JIANG
Author Information

1. 浙江大学医学院附属儿童医院消化内科
Keywords: Nanoparticles/toxicity; Zinc oxide/toxicity; Zinc oxide/pharmacology; Review
From: Journal of Zhejiang University. Medical sciences 2014;(2):218-226
CountryChina
Language:Chinese
Abstract: Zinc oxide nanoparticle ( nano-ZnO) has a size between 1 and 100 nm. Nano-ZnO has some special effects , such as small size effect , surface effect , quantum size effect , which makes it different from the ordinary ZnO , and is widely used in rubber industry , food processing , cosmetics and pharmaceutical fields .It has been reported that nano-ZnO has toxic effects in vitro and in vivo, but the mechanism of toxicity is still unclear.Therefore, it is important to evaluate the safety nano-ZnO by studying its biological toxic effects and related mechanisms . In this paper , we summarize the characterization , ingestion pathway , metabolism, systematic toxicity of nano-ZnO and its mechanisms , which may provide us with new strategy for the toxic research of nano-ZnO.