Survival time and related factors of antiretroviral therapy among HIV/AIDS patients in Liangshan Prefecture, during 2005-2015
10.3760/cma.j.cn112150-20200506-00691
- VernacularTitle:2005—2015年凉山彝族自治州艾滋病抗病毒治疗患者生存时间及相关因素分析
- Author:
Xue JIANG
1
;
Yan ZHAO
;
Chunnong JIKE
;
Jiali XU
;
Gang YU
;
Hailiang YU
;
Ju WANG
;
Decai ZHAO
;
Qiang LIAO
;
Xiumin GAN
;
Zhongfu LIU
Author Information
1. 北京市顺义区医院医院感染管理科 101300
- Keywords:
HIV;
Acquired immunodeficiency syndrome;
Sexually transmitted diseases, viral;
Survival time
- From:
Chinese Journal of Preventive Medicine
2020;54(11):1237-1242
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the survival time and to explore the releated factors of antiretroviral therapy among HIV/AIDS patients in LiangShan Prefecture, Sichuan Province for reduction of AIDS death rate.Methods:The retrospective research method was used to collect relevant information from the Management Database of Antiviral Treatment from the National AIDS Comprehensive Prevention Information System. The Kaplan-Meier method was used to describe the survival distribution and to analyze the survival time by single factor and the model of Cox proportional riskanalysis was performed to analyze the survival time of HARRT by multi-factors analysis.Results:Total 14 219 adults and young persons aged ≥15 HIV/AIDS patients received antiviral treatment from 2005 to 2015. The average age of all cases was (36.10±9.41) years old and 10 021 were males (70.5%). The main route of infection was intravenous drug use (61.0%, 8 678 cases). At the end of the observation, 10001 cases (70.3%) were still treated, and 1 425 cases (10.0%) died; Cox Regression analysis showed that female (0.67 (0.55-0.81)), route of sexual infection (0.67 (0.56-0.79)), baseline CD4 +T lymphocyte count 200-350 (0.41 (0.35-0.47)) and ≥350 (0.28 (0.24-0.34)), was a protective factor in death. At the beginning of treatment, the patient is clinically staging stage Ⅱ (0.70 (0.58-0.84)) and abnormal BMI (1.75 (1.50-2.03)), is a risk factor for death ( P<0.05). Conclusion:Early antiviral treatment is of great significance in improving the anti-viral treatment effect of AIDS. Compliance education should be further strengthened so as to enhance their knowledge. And it is feasible to enhance the effect of treatment through nutritional support for prolonging patients survival time and improving the quality of life.
