Study of Loss of Heterozygosity on Chromosome 9p21-22 in Sporadic Gliomas
10.3785/j.issn.1008-9292.2001.02.013
- VernacularTitle:神经胶质瘤中9p21-22区微卫星DNA的杂合性缺失研究
- Author:
Ke-Qing ZHU
1
;
Suo-Jiang ZHANG
Author Information
1. Zhejia ng University
- From:
Journal of Zhejiang University. Medical sciences
2001;30(2):87-89
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To Search allele loss in glioma at chromesome 9p21-22 by microsatellite.Methods:Loss of heterozy gosi ty (LOH) and Microsatellite instability(MSI) was examined in 29 gliomas using PC R based methods.Results:No LOH and MSI on chromosome 9p21-22 was de tected in 29 gliomas at three loci.Conclusion:①There may be no othe r suppressor gene at 9p21-22 in glioma except p15 and p16.②MSI is infrequent i n sporadic gliomas.
