The Establishment of a Novel Rat Model of Pancreas Transplantation
10.3785/j.issn.1008-9292.2001.02.003
- VernacularTitle:一种新型大鼠胰腺移植模型的建立
- Author:
Sheng YAN
1
;
Shu-Seng ZHENG
;
Guo-Ping JIANG
Author Information
1. The First Affiliated Hospital College of Medical Sciences
- From:
Journal of Zhejiang University. Medical sciences
2001;30(2):55-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To establish a rat model of pancr eas transplantation for basic research.Methods: The neck region of r at was selected as transplanting site and the operation was performed without cl amping the systemic circulation.The aortic segment of the graft was anastomosed with recipient's cervical artery by cuff technique,while the portal vein of the graft was anastomosed with recipient's jugular vein by microsurgical sewing.Flui d supplement and warm keeping was maintained after transplantation.Results : Seventy experiments were performed,among which 20 were former transplant ation.The total procedure of transplantation lasted about 1 hour and success rat e was 85%.The histological change was similar to those of clinical pancreas tran splantation.Conclusion: This pancreas transplantation model is simpl e and stable,while imitating the clinical procedure perfectly.It can be utilized in basic research of pancreas transplantation.
