Detection of Intercellular Adhesion Molecule-1 during Pediatric Cardiopulmonary Bypass
10.3785/j.issn.1008-9292.2000.02.006
- VernacularTitle:小儿体外循环手术围术期细胞间粘附分子-1的测定
- Author:
Jian-Hua LI
1
;
Ze-Wei ZHANG
;
Li-Qin CHEN
Author Information
1. The Affiliated Children's Hospital College of Medical Sciences Zhe jiang University
- Keywords:
Cell adhesion molecules/blood;
Heart defects,congenital/surg;
Extracorporeal circulation;
Postoperative period;
Children
- From:
Journal of Zhejiang University. Medical sciences
2000;29(2):63-66
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the role of serum intercellular adhesion molecule (ICAM-1)changes during pediatric cardiopulmonary bypass (CPB) surgery for congenital heart diseases (CHD)and the clinic significance of monitoring the serum ICAM-1 level. Methods: ICAM-1 levels were measured by double antibodies sandwich ELISA in arterial specimen from 33 CPB cases at various time points,the results were compared with those of 10 non-CPB patients and 30 normal children. Results:Patients with CHD had normal levels of serum ICAM-1 before surgery. The serum ICAM-1 levels in CPB group were significantly higher than those of controls (P〈0. 005). ICAM-1 levels started increasing as early as 30 minutes of CPB began and peaked 24 hours after surgery and stayed up 48 hours after surgery . The serum ICAM-1 levels in patients whose CPB lasted longer than 90 minuets were significantly higher (P<0.05). Conclusion:ICAM-1 showed higher and lasted longer after pediatric CPB surgery. The length of CPB is associated with elevation of ICAM-1. Monitoring of serumICAM-1 ,in certain degree,may help in predicting prognosis and complication after CPB surgery.
