Wireless closed-loop deep brain stimulation using microelectrode array probes

Jia Qianli; Liu Yaoyao; LV Shiya; Wang Yiding; Jiao Peiyao; XU Wei; XU Zhaojie; Wang Mixia; Cai Xinxia

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Wireless closed-loop deep brain stimulation using microelectrode array probes

Author: JIA QIANLI ^{1
,

2} ; LIU YAOYAO ; LV SHIYA ; WANG YIDING ; JIAO PEIYAO ; XU WEI ; XU ZHAOJIE ; WANG MIXIA ; CAI XINXIA
Author Information

1. State Key Laboratory of Transducer Technology,Aerospace Information Research Institute,Chinese Academy of Sciences,Beijing 100190,China
2. School of Electronic,Electrical and Communication Engineering,University of Chinese Academy of Sciences,Beijing 100049,China
Keywords: Deep brain stimulation(DBS); Wireless closed-loop deep brain stimulation(CL-DBS)microsystem; Microelectrode array(MEA)probe; Optical stimulation; Electrical stimulation
From: Journal of Zhejiang University. Science. B 2024;25(10):803-823
CountryChina
Language:Chinese
Abstract: Deep brain stimulation(DBS),including optical stimulation and electrical stimulation,has been demonstrated considerable value in exploring pathological brain activity and developing treatments for neural disorders.Advances in DBS microsystems based on implantable microelectrode array(MEA)probes have opened up new opportunities for closed-loop DBS(CL-DBS)in situ.This technology can be used to detect damaged brain circuits and test the therapeutic potential for modulating the output of these circuits in a variety of diseases simultaneously.Despite the success and rapid utilization of MEA probe-based CL-DBS microsystems,key challenges,including excessive wired communication,need to be urgently resolved.In this review,we considered recent advances in MEA probe-based wireless CL-DBS microsystems and outlined the major issues and promising prospects in this field.This technology has the potential to offer novel therapeutic options for psychiatric disorders in the future.