Key role of interferon regulatory factor 1(IRF-1)in regulating liver disease:progress and outlook
- Author:
CHEN TAO
1
;
LI SHIPENG
;
DENG DEWEN
;
ZHANG WEIYE
;
ZHANG JIANJUN
;
SHEN ZHONGYANG
Author Information
- Keywords: Interferon regulatory factor(IRF-1); Hepatitis virus; Liver fibrosis; Hepatic ischemia-reperfusion injury(HIRI); Liver cancer
- From: Journal of Zhejiang University. Science. B 2024;25(6):451-470
- CountryChina
- Language:Chinese
- Abstract: Interferon regulatory factor 1(IRF-1)is a member of the IRF family.It is the first transcription factor to be identified that could bind to the interferon-stimulated response element(ISRE)on the target gene and displays crucial roles in the interferon-induced signals and pathways.IRF-1,as an important medium,has all of the advantages of full cell cycle regulation,cell death signaling transduction,and reinforcing immune surveillance,which are well documented.Current studies indicate that IRF-1 is of vital importance to the occurrence and evolution of multifarious liver diseases,including but not limited to inhibiting the replication of the hepatitis virus(A/B/C/E),alleviating the progression of liver fibrosis,and aggravating hepatic ischemia-reperfusion injury(HIRI).The tumor suppression of IRF-1 is related to the clinical characteristics of liver cancer patients,which makes it a potential indicator for predicting the prognosis and recurrence of liver cancer;additionally,the latest studies have revealed other effects of IRF-1 such as protection against alcoholic/non-alcoholic fatty liver disease(AFLD/NAFLD),cholangiocarcinoma suppression,and uncommon traits in other liver diseases that had previously received little attention.Intriguingly,several compounds and drugs have featured a protective function in specific liver disease models in which there is significant involvement of the IRF-1 signal.In this paper,we hope to propose a prospective research basis upon which to help decipher translational medicine applications of IRF-1 in liver disease treatment.
