A study on the correlation of phthalate metabolites in umbilical cord blood of 161 newborns with birth indicators in Beijing
10.3760/cma.j.cn112150-20200211-00089
- VernacularTitle:北京市161名新生儿脐带血中邻苯二甲酸酯代谢物含量与出生指标的关联分析
- Author:
Hongjian MIAO
1
;
Lei ZHANG
;
Jianqiang LAI
;
Liang SUN
;
Yunfeng ZHAO
;
Jingguang LI
Author Information
1. 国家食品安全风险评估中心化学实验室 国家卫生健康委食品安全风险评估重点实验室，北京 100021
- Keywords:
Fetal blood;
Cross-sectional studies;
Phthalate metabolites
- From:
Chinese Journal of Preventive Medicine
2020;54(7):768-773
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation of phthalate metabolites in neonatal umbilical cord blood with birth indicators in Beijing, 2015.Method:From February to July in 2015, 161 pregnant women and their newborns who met the criteria were recruited from the Maternal and Child Health Hospital in Haidian District, Beijing. Questionnaires were used to collect the demographic information of pregnant women such as age, smoking, drinking, and cord blood after delivery. An ultra-high performance liquid chromatography-tandem mass spectrometry was used to determine the concentration of phthalate metabolites in umbilical cord blood. The multiple linear regression model was used to analyze the correlation of phthalate metabolites in umbilical cord blood with the neonatal weight, length, and ponderal index.Result:The age of 161 pregnant women was (30.3±3.0) years. The weight, length and ponderal index of 161 newborns were (3 447.2±413.0) kg, (50.2±1.1) cm, and (26.7±2.2) kg/m 3; 51.6% of newborns (83 cases) were boys. The concentrations of seven phthalate metabolites detected in umbilical cord blood, i.e., mono-methyl phthalate (MMP), mono-ethyl phthalate (MEP),mono-(2-isobutyl) phthalate (MiBP), mono-n-butyl phthalate (MBP), mono-ethylhexyl phthalate (MEHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), was (3.50±0.28), (2.65±0.47), (4.31±0.55), (6.26±0.57), (1.71±0.13), (1.10±0.09) and (0.47±0.06) ng/ml, respectively. The result of multiple linear regression model analysis showed that the concentrations of seven phthalate metabolites were not related to the neonatal weight, length, and ponderal index (all P values> 0.05). Conclusion:The concentrations of phthalate metabolites in neonatal umbilical cord blood are low, and they are not related to the neonatal weight, length, and ponderal index.
