Advances in the study of protein folding and endoplasmic reticulum-associated degradation in mammal cells

Cao Hong; Zhou Xuchang; XU Bowen; HU Han; Guo Jianming; MA Yuwei; Wang Miao; LI Nan; Zou Jun

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Advances in the study of protein folding and endoplasmic reticulum-associated degradation in mammal cells

Author: CAO HONG ^{1
,

2} ; ZHOU XUCHANG ; XU BOWEN ; HU HAN ; GUO JIANMING ; MA YUWEI ; WANG MIAO ; LI NAN ; ZOU JUN
Author Information

1. Department of Sport Rehabilitation,Shanghai University of Sport,Shanghai 200438,China
2. National Key Laboratory of Immunity and Inflammation,Naval Medical University,Shanghai 200433,China
Keywords: Endoplasmic reticulum-associated degradation(ERAD); Protein folding; Ubiquitination; Retrotranslocation
From: Journal of Zhejiang University. Science. B 2024;25(3):212-232,中插1-中插6
CountryChina
Language:Chinese
Abstract: The endoplasmic reticulum is a key site for protein production and quality control.More than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic reticulum.However,during protein folding,unfolded and/or misfolded proteins are prone to occur,which may lead to endoplasmic reticulum stress.Organisms can monitor the quality of the proteins produced by endoplasmic reticulum quality control(ERQC)and endoplasmic reticulum-associated degradation(ERAD),which maintain endoplasmic reticulum protein homeostasis by degrading abnormally folded proteins.The underlying mechanisms of protein folding and ERAD in mammals have not yet been fully explored.Therefore,this paper reviews the process and function of protein folding and ERAD in mammalian cells,in order to help clinicians better understand the mechanism of ERAD and to provide a scientific reference for the treatment of diseases caused by abnormal ERAD.