Advances in the study of mitophagy in osteoarthritis

Cao Hong; Zhou Xuchang; XU Bowen; HU Han; Guo Jianming; Wang Miao; LI Nan; Zou Jun

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Advances in the study of mitophagy in osteoarthritis

Author: CAO HONG ^{1
,

2} ; ZHOU XUCHANG ; XU BOWEN ; HU HAN ; GUO JIANMING ; WANG MIAO ; LI NAN ; ZOU JUN
Author Information

1. Department of Sport Rehabilitation,Shanghai University of Sport,Shanghai 200438,China
2. National Key Laboratory of Immunity and Inflammation,Naval Medical University,Shanghai 200433,China
Keywords: Mitophagy; Osteoarthritis; Chondrocyte; Mitochondria; Apoptosis
From: Journal of Zhejiang University. Science. B 2024;25(3):197-211
CountryChina
Language:Chinese
Abstract: Osteoarthritis(OA),characterized by cartilage degeneration,synovial inflammation,and subchondral bone remodeling,is among the most common musculoskeletal disorders globally in people over 60 years of age.The initiation and progression of OA involves the abnormal metabolism of chondrocytes as an important pathogenic process.Cartilage degeneration features mitochondrial dysfunction as one of the important causative factors of abnormal chondrocyte metabolism.Therefore,maintaining mitochondrial homeostasis is an important strategy to mitigate OA.Mitophagy is a vital process for autophagosomes to target,engulf,and remove damaged and dysfunctional mitochondria,thereby maintaining mitochondrial homeostasis.Cumulative studies have revealed a strong association between mitophagy and OA,suggesting that the regulation of mitophagy may be a novel therapeutic direction for OA.By reviewing the literature on mitophagy and OA published in recent years,this paper elaborates the potential mechanism of mitophagy regulating OA,thus providing a theoretical basis for studies related to mitophagy to develop new treatment options for OA.