Results of treatment of marrow failure by cyclosporine in Cho Ray Hospital during 1995-1999
- Author:
Oanh Hoang Le
- Publication Type:Journal Article
- Keywords:
bone marrow failure
- MeSH:
Bone Marrow Diseases;
Therapeutics;
Cyclosporine;
Hospitals
- From:Journal of Medical and Pharmaceutical Information
1998;(8):29-33
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
After 2 months, more patients in the cyclosporine group had a complete or partial remission in response to the treatment than did patients in the prednison group (53,85% and 7,69%; P<0,05), after 3 months this ratio is 69,23% and 16,67%; P<0,01. This difference was confirmed at 6 months 91,66% and 60%; P<0,05), after 12 months: 100% and 50% P>0,05. Hb concentration > 90g/l is 81,8% granulocyte counts >1,56G/l is 72,72%, platelet counts >100G/l is only 36,36%. 2 patients with responses in the cyclosponrine group relapsed after 24 months of treatment. Survival rate of patients in the cyclosporine group is 15/16 (93,57%) and in the prednison group is 6/15 (40%), P<0,05. Conclusion: Immunosuppressive treatment of aplastic anemia with cyclosponrine appears to be more effective than prednison and may represents a treatment of choice for patients with idiopathic aplastic anemia who are not eligible for bone marrow transplantation.
