Therapeutic advances in atrial fibrillation based on animal models

GONG QIAN; LE XUAN; YU PENGCHENG; ZHUANG LENAN

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Therapeutic advances in atrial fibrillation based on animal models

Author: GONG QIAN ^{1
,

2} ; LE XUAN ; YU PENGCHENG ; ZHUANG LENAN
Author Information

1. Institute of Genetics and Reproduction,College of Animal Sciences,Zhejiang University,Hangzhou 310058,China
2. Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province,Department of Cardiology,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China
Keywords: Atrial fibrillation; Animal model; Therapeutic
From: Journal of Zhejiang University. Science. B 2024;25(2):135-152
CountryChina
Language:Chinese
Abstract: Atrial fibrillation(AF)is the most prevalent sustained cardiac arrhythmia among humans,with its incidence increasing significantly with age.Despite the high frequency of AF in clinical practice,its etiology and management remain elusive.To develop effective treatment strategies,it is imperative to comprehend the underlying mechanisms of AF;therefore,the establishment of animal models of AF is vital to explore its pathogenesis.While spontaneous AF is rare in most animal species,several large animal models,particularly those of pigs,dogs,and horses,have proven as invaluable in recent years in advancing our knowledge of AF pathogenesis and developing novel therapeutic options.This review aims to provide a comprehensive discussion of various animal models of AF,with an emphasis on the unique features of each model and its utility in AF research and treatment.The data summarized in this review provide valuable insights into the mechanisms of AF and can be used to evaluate the efficacy and safety of novel therapeutic interventions.