A Meta-analysis of Pin1 gene polymorphism at -842 loci and cancer susceptibility
10.3760/cma.j.cn112150-20190425-00342
- VernacularTitle:Pin1基因-842G/C位点多态性与肿瘤易感性的Meta分析
- Author:
Mingting JIANG
1
;
Zhiren LIU
;
Jing HUANG
Author Information
1. 福建医科大学转化医学研究院，福州 350122
- Keywords:
Polymorphism, single nucleotide;
Neoplasms;
Meta-analysis;
Pin1
- From:
Chinese Journal of Preventive Medicine
2020;54(4):438-443
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Using Meta-analysis to evaluate the association between Pin1 gene polymorphism at -842 loci and cancer susceptibility.Methods:Pin1, polymorphism, tumor, variant and cancer as key words were used to systematically search for the case-control research on the association between the -842G/C polymorphisms of Pin1 and cancer susceptibility through China National Knowledge Infrastructure (CNKI), Wanfang Data, Embase and PubMed. The time of literatures was up to April 2 nd, 2019. Heterogeneity test, combined risk of cancer with the -842 C allele of Pin1, publication bias test and sensitivity analysis were performed by using Stata 12.0 software. Results:A total of 144 articles were retrieved. According to the inclusion criteria, a total of 11 articles were included (2 Chinese documents and 9 English documents). There were 5 667 cases and 6 120 controls in eligible articles. The heterozygous model showed that Pin1 (-842G/C) polymorphism was associated with cancer susceptibility, and the pooled OR (95 %CI) value was 0.78 (0.61, 0.99). Subgroup analysis by cancer type suggested that the Pin1 (-842G/C) polymorphism could significantly decrease the incidence of breast cancer and lung cancer under the heterozygous model (GC vs GG), dominant model (GC+CC vs GG) and allele model (C vs G). The pooled OR (95 %CI) values were 0.73 (0.58, 0.92), 0.71 (0.57, 0.89), and 0.73 (0.60, 0.89) in breast cancer and 0.64 (0.52, 0.78), 0.64 (0.53, 0.78), and 0.67 (0.55, 0.80) in lung cancer. The variant -842 C allele could significantly increase the risk of nasopharyngeal carcinoma under the homozygote model (CC vs GG) and recessive model (CC vs GG+GC). The pooled OR (95 %CI) values were 2.22 (1.03-4.75) and 2.47 (1.16-5.26). No significant association was observed in squamous cell carcinoma. Conclusion:This Meta-analysis demonstrated that Pin1gene polymorphism at -842 was associated with cancer susceptibility.
