Cost?effectiveness of potential government fully?funded influenza vaccination in population with diabetes in China
10.3760/cma.j.issn.0253?9624.2019.10.009
- VernacularTitle:中国糖尿病患者免费接种流感疫苗的成本效果分析
- Author:
Juan YANG
1
;
Han YAN
;
Luzhao FENG
;
Hongjie YU
Author Information
1. 复旦大学公共卫生学院流行病学教研室公共卫生安全教育部重点实验室
- Keywords:
Diabetes mellitus;
Influenza vaccines;
Government fully?funded vaccination;
Cost?effectiveness analysis
- From:
Chinese Journal of Preventive Medicine
2019;53(10):1000-1006
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the cost?effectiveness of potential government fully?funded influenza vaccination for diabetics in our country. Methods From the societal perspective, a decision tree model was developed to compare outcomes (including impact on the influenza?related outpatient consultation, hospitalization and excess mortality, and quality?adjusted life years (QALY), as well as incremental cost?effectiveness ratio (ICER)) of a national fully?funded vaccination programme in the population with diabetes and status quo (i.e., vaccinated with out?of?pocket payment, with a uptake rate of zero), using the published data with regarding to influenza related ILI (influenza?like illness) consultation rate, hospitalization rate and excess mortality rate, health?related quality of life and economic burden, diabetes prevalence, population size, health seeking behaviour, vaccine uptake rate, vaccine efficacy/effectiveness, etc. A time horizon of 1 year was used in the present analysis, and all costs were expressed in CNY in 2016 using the consumer price index. All results are presented in M (P25, P75). Results In the scenario of 40% vaccination coverage in the population with diabetes, government fully?funded vaccination programme was estimated to cost 1.71 (1.67, 1.75) billions CNY, and expected to prevent 110 000 (81 000, 143 000) influenza?related ILI consultations, 36 000 (28 000, 44 000) influenza?related SARI hospitalizations and 12 000 (9 000, 16 000) influenza?related deaths due to respiratory and cardiovascular diseases. A total of 108 000 (82 000, 142 000) QALY were estimated to be gained. The ICER was 10 088 (7 365, 14 046) CNY per QALY gained. The probability of cost?effectiveness of the fully?funded vaccination programme was 99.1% at a threshold of 53 680 CNY per QALY gained (GDP per capita in 2016). Conclusion Government fully?funded influenza vaccination in population with diabetes is cost?effective, and thus is recommended as the key strategy of diabetes prevention and control.
