Chronic Recurrent Cholangitis Induced by Carbamazepine.
- Author:
Sook Keun SONG
1
;
Yang Je CHO
;
Sang Hyun JANG
;
Kyoung Sub KIM
;
Byung In LEE
;
Kyoung HEO
Author Information
1. Department of Neurology, Yonsei University College of Medicine, Seoul, Korea. kheo@yuhs.ac
- Publication Type:Original Article
- Keywords:
Carbamazepine;
Cholangitis;
Adverse event
- MeSH:
Anticonvulsants;
Carbamazepine*;
Cholangitis*;
Hepatitis;
Humans;
Liver;
Necrosis;
Neuralgia;
Seizures
- From:Journal of Korean Epilepsy Society
2007;11(2):106-108
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Carbamazepine (CBZ) is one of the most commonly used antiepileptic agents. With its potent effects against seizure or neuropathic pain, it also has several undesirable adverse events. CBZ has been known to induce hepatotoxicity because the drug is mainly metabolized through hepatic system, and asymptomatic liver enzyme elevation occurs in 5~10% of patients receiving CBZ. There are several cases of symptomatic hepatitis or hepatic necrosis by CBZ, however, reports of chronic cholangitis associated with CBZ medication are rare. Here, we present a case of chronic recurrent cholangitis by CBZ with pathological evidence.
