Association of single nucleotide polymorphisms of TBX 5 gene and environmental exposure index with susceptibility to oral cancer
10.3760/cma.j.issn.0253?9624.2019.05.009
- VernacularTitle:TBX5基因多态性、环境暴露指数与口腔癌发病风险的关联研究
- Author:
Xiaodan BAO
1
;
Lisong LIN
;
Fa CHEN
;
Fengqiong LIU
;
Jing WANG
;
Bin SHI
;
Lingjun YAN
;
Junfeng WU
;
Liangkun LIN
;
Rui WANG
;
Lizhen PAN
;
Xiaoyan ZHENG
;
Yu QIU
;
Rongkai CAO
;
Zhijian HU
;
Lin CAI
;
Baochang HE
Author Information
1. 福建医科大学公共卫生学院流行病与卫生统计学系/福建省环境因素与肿瘤重点实验室
- Keywords:
Mouth neoplasms;
Case?control studies;
Environmental exposure;
TBX5 gene
- From:
Chinese Journal of Preventive Medicine
2019;53(5):480-485
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association of TBX 5 polymorphisms and environmental exposure index with susceptibility to oral cancer. Methods A case?control study was conducted to collect 300 oral cancer patients hospitalized in the Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Fujian Medical University from September 2010 to December 2016. A total of 445 non?tumor patients were selected as the control group. Questionnaires were used to collect the information of all subjects and 5 ml peripheral blood was collected to detect single nucleotide polymorphisms (SNPs) of the rs10492336 locus of TBX5 gene. According to the environmental exposure index score, subjects were divided into two groups, low risk group (0-2.31) and high risk group (2.32-11.76). To analyze the association of TBX5 gene rs10492336 SNPs, environmental exposure index and oral cancer and its interactions. Results The age of all subjects in the case group and control group were (56.19±13.10) years and (54.56± 12.48) years old. Compared with CC genotype, the OR (95%CI) values of the co?dominant genetic model AC genotype and the dominant genetic model AC+AA genotype were 0.69 (0.49-0.98) and 0.70 (0.51-0.97), respectively. Compared with the low risk group, the OR (95%CI) risk of oral cancer in the high risk group was 3.72 (2.55-5.43). The results of gene?environment interaction analysis showed that compared with the group with CC genotype and high risk of environmental exposure index, the OR (95%CI) value of oral cancer in the group with AC+AA genotype and low risk of environmental exposure index was 0.18(0.10-0.31). Furthermore there was a multiplicative interaction between rs10492336 SNPs and environmental exposure index (β=-0.405, P<0.001). Conclusion This study suggests that the TBX 5 gene rs10492336 SNPs and environmental exposure index were associated with oral cancer. And there was a multiplication interaction between rs10492336 SNPs and environmental exposure index.
