Pharmacokinetics of gemcitabine in Chinese patients with non-small-cell lung cancer
- Author:
Lin-Run WANG
1
;
Ming-Zhu HUANG
;
Nong XU
;
Jian-Zhong SHENTU
;
Jian LIU
;
Jie CAI
Author Information
1. 浙江大学
- Keywords:
Gemcitabine;
Non-small-cell lung cancer;
Pharmacokinetics
- From:
Journal of Zhejiang University. Science. B
2005;6B(5):446-450
- CountryChina
- Language:Chinese
-
Abstract:
To determine the pharmacokinetics of gemcitabine (2',2'-difluorodeoxycytidine) in Chinese non-small-cell lung cancer (NSCLC) patients. Six study subjects were administered gemcitabine at a fixed dose rate of 10 mg/m2 per min (1200 mg/m2,two hours infusion) and carboplatin, and plasma gemcitabine concentrations were measured by ion-pair reversed-phase high-performance liquid chromatography (HPLC). 3P97 Pharmaceutical Kinetics Software was used for the calculation of pharmacokinetic parameters. The obtained mean parameters, elimnation half life (t1/2) (10.67±3.38 min), area under the curve hematologic toxicology result showed that the regimen was effective on and tolerated by the patients.
