Research progress on epigenetic mechanism of reproductive disorders

VernacularTitle:生殖障碍性疾病表观遗传机制的研究进展
Author: Nan JIANG ¹ ; Xiaoli ZHAO ; Jiaqi XU ; Kaixi LI ; Tian XIA
Author Information

1. 天津中医药大学第一附属医院　国家中医针灸临床医学研究中心，天津　300380
Keywords: Epigenetic inheritance; Reproductive disorder; DNA methylation; Histone modification; miRNA
From: Chinese Journal of Medical Genetics 2024;41(11):1393-1398
CountryChina
Language:Chinese
Abstract: The "Developmental Origins of Health and Disease, DOHaD" theory suggests that adverse factors in early life can lead to the occurrence of chronic diseases in adulthood. In recent years, it has been discovered that maternal factors, intrauterine development environment and environmental exposure during pregnancy can mediate the changes of early egg/embryo development, promote the occurrence of reproductive disorders such as polycystic ovary syndrome, diminished ovarian reserve, and endometriosis, and induce intergenerational genetic effects. This article has reviewed the progress of research on maternal factors which may affect the pathogenesis of reproductive disorders, and expounds its mechanism from the perspectives of epigenetic mechanisms such as DNA methylation, histone modification and non-coding small RNA (miRNA) modification, with an aim to provide insights for studying the occurrence of adult reproductive disorders in early life and before pregnancy.