Prevalence and Genotype Distribution of Cervical Human Papillomavirus DNA in Korean Women: A Multicenter Study.
- Author:
Sung Ran HONG
1
;
In Sun KIM
;
Dong Won KIM
;
Mi Jin KIM
;
Ae Ree KIM
;
Young Ok KIM
;
Hye Sun KIM
;
Seo Hee RHA
;
Gyeong Sin PARK
;
Yong Koo PARK
;
Yong Wook PARK
;
Ho Sung PARK
;
Kwang Sun SUH
;
Jin Hee SOHN
;
Mi Kyung SHIN
;
Hoon Kyu OH
;
Ki Jung YUN
;
Hye Kyoung YOON
;
Shi Nae LEE
;
Ah Won LEE
;
Hyo Jin LEE
;
Hyun Yee CHO
;
Chan CHOI
;
Woon Won JUNG
Author Information
1. Department of Pathology, Kwandong University Cheil General Hospital & Women's Healthcare Center, Seoul, Korea.
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Uterine cervix;
Human papillomavirus;
DNA chips;
Papanicolaou test;
South Korea
- MeSH:
Cervix Uteri;
DNA;
Female;
Genotype;
Humans;
Mass Screening;
Oligonucleotide Array Sequence Analysis;
Population Characteristics;
Prevalence;
Republic of Korea;
Vaccination;
Vaginal Smears
- From:Korean Journal of Pathology
2009;43(4):342-350
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background: DNA prevalence and type distribution of human papillomavirus (HPV) varies geographically. We investigated HPV prevalence and type distribution in Korean women using the MyHPV DNA chip testing. Methods: A total of 2,368 women from five regions of the country underwent Pap smear examination and MyHPV chip testing. Results: Overall HPV positivity was 15.8% and 78.4% in women with normal and abnormal cytology, respectively. High-risk HPV infection was strongly correlated with cytological atypia. In women with abnormal cytology, the five most common HPV types were 16, 58, 18, 52, and 56/53, and HPV16 was significantly the most common type in most geographical regions. After HPV16, HPV58, and 52 were the next most frequently detected types. Women with normal cytology, in contrast, showed heterogeneity in HPV type distribution. High-grade intraepithelial lesions infected with HPV16, 18, 31 or 45 are more likely to progress to carcinoma. Conclusions: The HPV chip test can provide useful data regarding HPV positivity and type. The most common HPV type in Korean women with abnormal cytology is HPV16, with HPV58 and 52 being frequently present. Our data may have important implications for vaccination programs and the development of cervical screening.
